Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria
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چکیده
منابع مشابه
Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.
Ribosomes synthesizing proteins containing consecutive proline residues become stalled and require rescue via the action of uniquely modified translation elongation factors, EF-P in bacteria, or archaeal/eukaryotic a/eIF5A. To date, no structures exist of EF-P or eIF5A in complex with translating ribosomes stalled at polyproline stretches, and thus structural insight into how EF-P/eIF5A rescue ...
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Decoding of aberrant mRNAs leads to unproductive ribosome stalling and sequestration of components of the translation machinery. Bacteria have evolved three seemingly independent pathways to resolve stalled translation complexes. The trans-translation process, orchestrated by the hybrid transfer-messenger RNA (tmRNA) and its essential protein co-factor, small protein B (SmpB), is the principal ...
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During translation initiation, eukaryotic initiation factor 2 (eIF2) delivers the Met-tRNA to the 40S ribosomal subunit to locate the initiation codon (AUGi) of mRNA during the scanning process. Stress-induced eIF2 phosphorylation leads to a general blockade of translation initiation and represents a key antiviral pathway in mammals. However, some viral mRNAs can initiate translation in the pre...
متن کاملinvestigating cda tendency and critical thinking abilities of iranian translation students in relation to their translation quality
امروزه مسئله ی اساسی در رویکرد های جدید زبانشناسی، ابعاد اجتماعی و ایدئولوژیک زبان تلقی می شود. گروه های مختلف اجتماعی، سیاسی و یا مذهبی از زبان به عنوان ابزاری برای دستیابی به اهداف درون گروهی خود استفاده می کنند (ون دایک، 2003). آنها معولا ایدئولوژی خود را صریحا ابراز نمی کنند بلکه آن را در غالب کلمات و ساختارهای زبانی پنهان نگه می دارند. تشخیص ایدئولوژی های پنهان در گفتمان نیازمند این موضوع ...
construction and validation of translation metacognitive strategy questionnaire and its application to translation quality
like any other learning activity, translation is a problem solving activity which involves executing parallel cognitive processes. the ability to think about these higher processes, plan, organize, monitor and evaluate the most influential executive cognitive processes is what flavell (1975) called “metacognition” which encompasses raising awareness of mental processes as well as using effectiv...
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ژورنال
عنوان ژورنال: eLife
سال: 2020
ISSN: 2050-084X
DOI: 10.7554/elife.61984